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Vitamin D regulates contractile profile in human uterine myometrial cells via NF-κB pathway.

Identifieur interne : 000845 ( Main/Exploration ); précédent : 000844; suivant : 000846

Vitamin D regulates contractile profile in human uterine myometrial cells via NF-κB pathway.

Auteurs : Chandrasekhar Thota [États-Unis] ; Archana Laknaur [États-Unis] ; Takeisha Farmer [États-Unis] ; Gwinnett Ladson [États-Unis] ; Ayman Al-Hendy [États-Unis] ; Nahed Ismail [États-Unis]

Source :

RBID : pubmed:24262718

Descripteurs français

English descriptors

Abstract

Infection triggers inflammation that, in turn, enhances the expression of contractile-associated factors in myometrium and increases the risk of preterm delivery. In this study, we assessed vitamin D regulation of inflammatory markers, contractile-associated factors, steroid hormone receptors, and NFκB pathway proteins in human uterine myometrial smooth muscle (UtSM) cells that were cultured in an inflammatory environment.

DOI: 10.1016/j.ajog.2013.11.027
PubMed: 24262718


Affiliations:


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<div type="abstract" xml:lang="en">Infection triggers inflammation that, in turn, enhances the expression of contractile-associated factors in myometrium and increases the risk of preterm delivery. In this study, we assessed vitamin D regulation of inflammatory markers, contractile-associated factors, steroid hormone receptors, and NFκB pathway proteins in human uterine myometrial smooth muscle (UtSM) cells that were cultured in an inflammatory environment.</div>
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